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  • GPhC gives green light for revalidation for pharmacy professionals

    GPhC gives green light for revalidation for pharmacy professionals

    Wednesday, 13 December 2017 12:28
  • Community pharmacy not perceived as an ‘appropriate setting’ for NHS Health Check

    Community pharmacy not perceived as an ‘appropriate setting’ for NHS Health Check

    Tuesday, 12 December 2017 12:05
  • NICE publishes new asthma guidelines

    NICE publishes new asthma guidelines

    Friday, 01 December 2017 10:25
  • Community Pharmacy Practitioner Champions details confirmed for 2017-18

    Community Pharmacy Practitioner Champions details confirmed for 2017-18

    Monday, 27 November 2017 14:45
  • MHRA targets OTC medicines in Yellow Card social media campaign

    MHRA targets OTC medicines in Yellow Card social media campaign

    Wednesday, 22 November 2017 15:19

Umesh Modi is a chartered accountant, and Pamini Jatheeskumar is a chartered certified accountant at Silver Levene...
  Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead...
Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead pharmacist, Health and Wellbeing Directorate, Public Health England
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drugalertJune 27 2016

The tablet and oral suspension preparations of Noxafil (posaconazole) are not interchangeable, the European Medicines Agency has warned. Due to the formulations not having the same pharmacokinetics, there are concerns that patients may be receiving an ineffective dose or overdose if there has been a change from the prescribed formulation.

EMA issued the warning on Friday saying that Noxafil is available as 100mg tablets or as a 40mg/ml oral suspension. The drug is indicated for a number of fungal infections where other antifungal agents are ineffective or not suitable for use, and for prophylactic use in certain other circumstances.

“The recommended oral dosage is 300 mg once a day with the tablets (after a loading dose of 300 mg twice daily on day 1) and 200 mg three to four times a day (600 to 800 mg daily) with the oral suspension,” said EMA. “Medication errors have been reported following erroneous switching, resulting in over or under-dosage and consequent dose-related toxicity or lack of efficacy.

“It is important that the dosage form as well as the relevant dose be specified on the prescription, and that pharmacists ensure the correct oral dosage form is dispensed.”

EMA has said that the Summary of Product Characteristics (SmPC) and patient information leaflet (PIL) for Noxafil are being updated to strengthen warnings about the differences between the two formulations. In addition, “the outer cartons will be revised to further differentiate the two and to include a warning statement that they cannot be simply substituted without adjusting the dose.”

It will be writing to health professionals to remind them of the issue.

Link:

EMA announcement

Practice News

December 13 2017 The new revalidation process for pharmacists and pharmacy technicians will come into effect from March 30 2018, the General Pharmaceutical Council has announced.
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