DOACs associated with reduced risk of major bleeding compared to warfarin

DOACs associated with reduced risk of major bleeding compared to warfarin

July 11 2018 Direct oral anticoagulants (DOACs) have been associated with reduced risks of major...

Recorded penicillin allergy associated with increased risk of MRSA and C difficile

Recorded penicillin allergy associated with increased risk of MRSA and C difficile

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Syphilis and gonorrhoea diagnoses see significant increase

Syphilis and gonorrhoea diagnoses see significant increase

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Anticholinergics linked to increased risk of dementia

Anticholinergics linked to increased risk of dementia

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Women of childbearing potential must be on Pregnancy Prevention Programme if taking valproate

Women of childbearing potential must be on Pregnancy Prevention Programme if taking valproate

April 26 2018 Women and girls of childbearing potential must no longer take valproate medicines...

  • DOACs associated with reduced risk of major bleeding compared to warfarin

    DOACs associated with reduced risk of major bleeding compared to warfarin

    Wednesday, 11 July 2018 13:11
  • Recorded penicillin allergy associated with increased risk of MRSA and C difficile

    Recorded penicillin allergy associated with increased risk of MRSA and C difficile

    Tuesday, 03 July 2018 16:42
  • Syphilis and gonorrhoea diagnoses see significant increase

    Syphilis and gonorrhoea diagnoses see significant increase

    Monday, 11 June 2018 14:16
  • Anticholinergics linked to increased risk of dementia

    Anticholinergics linked to increased risk of dementia

    Monday, 30 April 2018 12:08
  • Women of childbearing potential must be on Pregnancy Prevention Programme if taking valproate

    Women of childbearing potential must be on Pregnancy Prevention Programme if taking valproate

    Thursday, 26 April 2018 11:48

Umesh Modi is a chartered accountant, and Pamini Jatheeskumar is a chartered certified accountant at Silver Levene...
  Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead...
Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead pharmacist, Health and Wellbeing Directorate, Public Health England
More inWhite Papers  

a pregnant woman pharmacyMarch 29 2018

Mefloquine is safe to use for malaria prevention during pregnancy, a Cochrane review has concluded.

After reviewing five studies relating to the drug’s use in sub-Saharan Africa and one in Thailand between 1987 and 2013, the Cochrane authors said that “mefloquine is efficacious and safe for prevention of malaria in pregnant women living in stable transmission areas.

“The drug has been found to be safe in terms of adverse pregnancy outcomes, such as low birth weight, prematurity, stillbirths and abortions, and congenital malformations. However, it is worse tolerated than other antimalarial drugs.”

Data included in the review covered women living with and without having HIV infection. It also found relative efficacy relating to other malarial chemophrophylaxis. “Mefloquine was more efficacious than sulfadoxine-pyrimethamine in HIV-uninfected women or daily cotrimoxazole prophylaxis in HIV-infected pregnant women for prevention of malaria infection.”

However, in all circumstances, mefloquine “increases risks of drug-related adverse events including vomiting, fatigue/weakness, and dizziness,” said the reviewers. “Overall, the high proportion of mefloquine-related adverse events constitutes an important barrier to its effectiveness for malaria preventive treatment in pregnant women.”

The Summary of Product Characteristics for Larium notes that mefloquine is teratogenic in mice and rats, and embryo-toxic in rabbits, “however, large clinical experience with Lariam as prophylactic treatment has not revealed an embryotoxic or teratogenic effect.”

Links:
Cochrane Library announcement          http://www.cochrane.org/CD011444/INFECTN_mefloquine-preventing-malaria-pregnant-women
http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD011444.pub2/full
Larium SPC      

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