MHRA issues DRUs covering gabapentin, methylprednisolone, clozapine and isotretinoin

MHRA issues DRUs covering gabapentin, methylprednisolone, clozapine and isotretinoin

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Study finds ibuprofen is linked to blood pressure rise in arthritis patients at cardiovascular risk

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Steroids are not effective for chest infection, new study finds

Steroids are not effective for chest infection, new study finds

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  • MHRA issues DRUs covering gabapentin, methylprednisolone, clozapine and isotretinoin

    MHRA issues DRUs covering gabapentin, methylprednisolone, clozapine and isotretinoin

    Tuesday, 31 October 2017 20:03
  • PPIs may add to liver disease problems in people with alcohol dependency, suggests study

    PPIs may add to liver disease problems in people with alcohol dependency, suggests study

    Tuesday, 17 October 2017 14:27
  • Pregnant women are not always informed of risks associated with sodium valproate

    Pregnant women are not always informed of risks associated with sodium valproate

    Tuesday, 26 September 2017 14:14
  • Study finds ibuprofen is linked to blood pressure rise in arthritis patients at cardiovascular risk

    Study finds ibuprofen is linked to blood pressure rise in arthritis patients at cardiovascular risk

    Monday, 04 September 2017 15:12
  • Steroids are not effective for chest infection, new study finds

    Steroids are not effective for chest infection, new study finds

    Thursday, 31 August 2017 12:57

Umesh Modi is a chartered accountant, and Pamini Jatheeskumar is a chartered certified accountant at Silver Levene...
  Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead...
Don Lavoie is alcohol programme manager at Public Health England and Gul Root is lead pharmacist, Health and Wellbeing Directorate, Public Health England
More inWhite Papers  

a woman coughing image cbAugust 31 2017

Oral corticosteroids do not reduce the symptom duration or severity of acute lower respiratory tract infections in adults who do not have asthma, a study has concluded.

 Researchers studied outcomes in 398 non-asthmatic adults who were given prednisolone 40mg once daily for five days. Median cough duration was five days in both the prednisolone and placebo groups. Mean symptom severity was 1.99 points in the prednisolone group and 2.16 points in the placebo group.

In addition, “no significant treatment effects were observed for duration or severity of other acute lower respiratory tract infection symptoms, duration of abnormal peak flow, antibiotic use, or non-serious adverse events.”

The UK study was funded by NIHR School for Primary Care Research and published in JAMA.

Alastair Hay, a GP and Professor of Primary Care in the Bristol Medical School at the University of Bristol and lead author, said: “Chest infections are one of the most common problems in primary care and often treated inappropriately with antibiotics. Corticosteroids, like prednisolone, are increasingly being used to try to reduce the symptoms of chest infections, but without sufficient evidence.

“Our study does not support the continued use of steroids as they do not have a clinically useful effect on symptom duration or severity. We would not recommend their use for this group of patients.”

Links:
NIHR announcement      
NIHR SPCR announcement            
AD Hay et al. ‘Effect of Oral Prednisolone on Symptom Duration and Severity in Non-asthmatic Adults With Acute Lower Respiratory Tract Infection’. JAMA. 2017;318(8):721-730.  

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