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  • BMJ: ‘Adding a sulfonylurea to metformin looks safer than switching to one’

    BMJ: ‘Adding a sulfonylurea to metformin looks safer than switching to one’

    Wednesday, 25 July 2018 14:07
  • Effect of omega-3 or other fatty acids on heart disease is negligible finds Cochrane review

    Effect of omega-3 or other fatty acids on heart disease is negligible finds Cochrane review

    Thursday, 19 July 2018 10:36
  • DOACs associated with reduced risk of major bleeding compared to warfarin

    DOACs associated with reduced risk of major bleeding compared to warfarin

    Wednesday, 11 July 2018 13:22
  • Recorded penicillin allergy associated with increased risk of MRSA and C difficile

    Recorded penicillin allergy associated with increased risk of MRSA and C difficile

    Tuesday, 03 July 2018 16:51
  • MPS advises of need for better awareness of cauda equina red flag symptoms

    MPS advises of need for better awareness of cauda equina red flag symptoms

    Wednesday, 09 May 2018 16:01

inhalerMarch 23 2016

While inhaled corticosteroids are known to increase the risk of pneumonia in chronic obstructive pulmonary disease, the benefits outweigh the risks, a review has concluded.

Carried out by the European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAC), the study also looked at whether there were any differences in the risk of pneumonia between products. It “did not find conclusive evidence of such difference. Pneumonia remains a common side effect for all of them,” said EMA.

“The Committee’s view is that the benefits of inhaled corticosteroids continue to outweigh their risks.” The committee has recommended that product information is updated “to adequately reflect the current knowledge”.

EMA has said that the findings mean that there will be no change to the way these medicines should be used. However, it says doctors and patients should be “vigilant for signs and symptoms of pneumonia in patients with COPD as the clinical features of pneumonia overlap with those of exacerbations of the underlying disease.”

Before the recommendation is adopted as the EMA’s final opinion, the PRAC recommendation will be considered by the Committee for Medicinal Products for Human Use (CHMP). “Further details including advice for patients and healthcare professionals will be published at the time of the CHMP opinion,” said EMA.

In a separate EMA announcement, the PRAC has issued advice for doctors and patients using the cancer medicine Zydelig (idelalisib) for chronic lymphocytic leukaemia (CLL) or who have follicular lymphoma (FL). In particular, patients should receive antibiotics to prevent Pneumocystusjirovecii pneumonia developing, it has advised. Patients should also be monitored for infection and have regular blood tests for white blood cell counts.

Links:

EMA inhaled corticosteroids announcement 

EMA Zydelig announcement

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